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Emerging technologies, including brain organoids and microfluidic “organ-on-chip” platforms, provide enhanced physiological relevance by simulating multicellular brain environments and nutrient flow (Castiglione et al., 2022)
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Many studies evaluating cardioprotective phytochemicals are preclinical in nature, with heterogeneous designs and objectives and a tendency toward short study durations, which may limit the strength of evidence regarding long-term clinical benefits [311,312,313]
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